In order to prove the role of solid lipid nanoparticles in oral absorption and bioavailability, the biodegradable monoglyceride with low toxicity and good biocompatibility is used as lipid materials to prepare nanoparticles of digoxin solid lipid and carry out research on polyethylene glycol aimed at the low utilization of digoxin in this research, in order to provide experimental basis for the development of new preparation system of digoxin. The results of the research show that the solid lipid nanoparticles prepared by the combination of ionic compound and solvent diffusion method can achieve effective encapsulation and high-efficiency load of water- soluble digoxin, and improve the absorption effect and bioavailability. Based on the preparation of polyethylene glycol-modified nanoparticles of digoxin solid lipid, it is expected to reduce the amount of usage and side effects of digoxin.
