Objective: To study the failure analysis system by means of chemical equipment computer. Methods: To test and detect the failure of parts of chemical equipment, then determine the form of failure, find out the main cause of failure, and study the related improvement and preventive measures. Results: The cause and mode of failure are found out timely and accurately. Conclusion: The application of chemical assembly computer in the study of failure analysis system has obvious effect and it is beneficial to improve the accuracy of research results, so it has higher application value.