Chemical enterprises belong to one of the important basic industries in China. The human resources management is the key to improve the market competitiveness of chemical enterprises. Based on the theory of modern human resources management, this paper analyses and studies the present situation and problems of human resources management in chemical enterprises and puts forward the measures and schemes of constructing human resource management mechanism in chemical enterprises. This paper makes clear that the core of human resource management is people-oriented, and the perfect human resource management mechanism is the basis of enterprises maintaining the core power in the market competition. This paper analyses and discusses the existing problems and shortcomings in human resources management of chemical enterprises in China and puts forward corresponding improvement measures from performance evaluation system, staff training system and mechanism system in order to enlighten and provide reference to relevant employees.