Continuous Preferential Crystallization in Two Coupled Crystallizers

Abstract

This contribution investigates continuous preferential crystallization in two coupled vessels connected via liquid exchange to resolve enantiomers from a racemic mixture. A comparison is drawn between separation in single and two coupled crystallizers. Implementation of periodic and continuous seeding modes is analyzed as well as the influence of exchange flow rate. A high resolution scheme of Koren is applied to solve the models considered. Productivity, purity and mean crystal size are chosen as goal functions to evaluate the product quality and advantages of the coupled process.