The implementation of the inherent safety principles could be ambiguous due to the strategies that are involved on. Optimization is one of the options that could be seen as the key to balance the risk reduction and the economic feasibility of the project. The utilization of safety index is another option, with lower time efficiency and related results. The present paper will focus on the implementation of inherent safety principles into the biofuels production. The starting point is related to the chemist modification, passing from the common trans-esterification reaction to a two steps process, a hydrolysis of the triolein and with the fatty acid obtained do an esterification with methanol. The software selected for the project development is Aspen Plus and the reduction on the process risk will be evaluated with process safety indexes. The latter involve the characteristics of the process, type of equipment and the most important thing the type of substance that is handled on each unit.
