Lyagin E., Drews A., Bhattacharya S., Kraume M., 2012, Membrane Reactor System for Parallel Continuous Screening and Characterisation of Biocatalysts, Chemical Engineering Transactions, 27, 319-324.
Reliable bioprocess design requires the estimation of “true” kinetic parameters, which should be the same for both scales - the lab-scale and the process scale. However, commercially available screening and characterisation systems are mostly operated in batch/fed-batch mode, which is not sufficient to describe the continuous operational mode that is typically used for native enzyme applications. So, a new concept of membrane based screening and characterisation system that enables physical retention of the dissolved catalyst is proposed and developed.
