Abstract
The novel titanium(IV) complexes of composition [TiCl2(SB)2] have been synthesized by reacting TiCl4 and Schiff bases (SBs) where (SBs = A1( tetracycline hydrochloride schiffs base) ;B1(Streptomycin schiffs base ) ;C1( Ceffixime schiffs base) ;D1( ampicillin schiffs base) in fixed molar ratio 1:2. Titanium and chlorine estimation were estimated by gravimetrical and Volhard method respectively. These were characterized by Mass, IR, UV- Visible, 1H-NMR spectral techniques. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. Bacillus cereus MTCC 6728, Micrococcus luteus MTCC 1809, Staphylococcus aureus MTCC 3160, Staphylococcus epidermidis MTCC 3086, Aeromonas hydrophila MTCC 1739, Aclaligenes faecalis MTCC 126, Shigella sonnei MTCC 2957, Klebsiella pneumoniae MTCC 3384, Pseudomonas aeruginosa MTCC 1035, and Salmonella typhimurium MTCC 1253. It was found that metal complexes have more antimicrobial activity than their parent Schiff bases.
