The present study focuses on the analysis of domino effect triggered by overpressure caused by blast waves due to explosions derived by deliberate attacks to process plants and carried out with home-made explosives. The effects of blast waves caused by home-made explosives were compared with those expected from a net equivalent charge of TNT by using a specific methodology for the assessment of stand-off distances. The methodology was applied to a case study demonstrating the potentiality of home- made explosives in causing accident escalation and severe effects on population and assets, obtaining indications for the importance of adequate management of site security.