Enayati Ahangar L., Movassaghi K., Bahrami F., Enayati M., Chianese A., 2014, Determination of Drugs in Biological Sample by Using Modified Magnetic Nanoparticles and HPLC, Chemical Engineering Transactions, 38, 391-396.
A microextraction method using Ag modified-magnetic nanoparticle (Ag-MNPs) coupled with high performance liquid chromatography (HPLC) has been applied for determination of cefteriaxone in plasma. Magnetic nanoparticles were synthesized via a mild solution route. The prepared nanoparticles were modified with a thin layer of silver and characterized with different methods such as X-ray diffraction (XRD), transmission electron microscopy (TEM), FTIR and ultraviolet-visible(UV-Vis) spectroscopy. Effect of several parameter such as pH of donor and acceptance phase, amount of magnetic particle and extraction and desorption time were optimized. Under the optimal condition the enrichment factor was obtained 19. The detection limit was 0.02 mg/mL and a wide linear range as 0.06 to 40µg/mL were obtained.
