Wang J., Xie C., Yin Q., Tao L., Lv J., Wang Y., Hao H., 2016, Preparation and Characterization of Nanoparticles of Amorphous Cefmenoxime Hydrochloride, Chemical Engineering Transactions, 47, 427-432.
Poor water solubility of cefmenoxime hydrochloride greatly limits its bioavailability and clinical application. The decreasing of the particle size could significantly enhance the solubility of the solute. In this work, nanoparticles of amorphous cefmenoxime hydrochloride with nano-size were successfully prepared by the methods of cooling crystallization, anti-solvent crystallization and emulsion crystallization. Different stabilizers, such as Tween 80 and Polyvinylpyrrolidone, were tried to prevent particles from agglomeration and growth. The final products were characterized by scanning electron microscopy, transmission electron microscopy and powder X-ray diffraction. Results show that different preparation methods have significant impacts on morphology of particles. Products prepared by cooling crystallization are smooth spherical with a central hole while products prepared by anti-solvent crystallization are agglomerated seriously and products prepared by emulsion crystallization have not specific shapes. Although the addition of stabilizers don’t show an effective effect on preventing particle growth or enhancing particles stability, they have effect on the morphology of the particles, especially for Tween 80.
