Abstract
Research on nanomaterials has become a hot field of materials, which involves physics, chemistry, biology and other disciplines. In this paper, MSNs and MWCNTs were used for the study. By topical route of administration, we study the reaction in mice after application on the immune toxicity of nanomaterials to provide a theoretical basis for the application in pancreatic cancer. With the rapid development of nano- medicine, nano-materials, the body's immune response began to attract attention. The study of nanomaterials in the blood circulation and thus enhancing protein adsorption or suppress the immune response. In recent years, nanomaterials include carbon nanotube, baby ball, fullerene, and emulsions, applicated in immune response and immune therapy. Immune suppression is by inhibiting the proliferation or function of immune- related cells, thereby inhibiting the body's immune response. Immunosuppression is double-edged sword, on the one hand, immune suppression and infection reduces the body's defense ability of cancer cells. On the other hand, it was able to reduce the rejection of organ transplants, but also improve the allergic diseases and autoimmune disease and treatment results. The study found that immunosuppressed mice inhaled carbon nanotubes may activate alveolar cyclooxygenase pathway signal to the spleen.
