Abstract
In this paper, we use the computer process simulation software UniSim Design R400 to simulate the operation of the penicillin fermentation device, apply the gravitation search algorithm to find the optimal parameters for the model, and take the forms of non-structural kenetic models for bacteria, products, substrate and volume into account, so as to determine the mathematical model to describe penicillin fermentation. We set up a process flow diagram (PFD) for penicillin fermentation, establish an initialization module, supplemented medium module and fermentation tank module. By changing the initial conditions, setting equipment failures and implementing different control strategies, we further study the working conditions for penicillin fermentation according to the established PFD to help people predict problems that they may encounter in the actual experiment or production.
