This paper studies the data preprocessing technology in chemical process data mining. It mainly studies the real-time chemical process data in-depth from the perspective of software development and explores various kinds of real-time data preprocessing methods. The enterprise pre-processes real-time data based on the MES data mining system and other systems associated with real-time data to develop a real-time data preprocessing system based on the theory. In addition to acquisition and storage of real-time data, this system corrects false data and fills missing data to provide accurate and credible data for data mining tools. Finally, the real-time data preprocessing system integration is applied to data mining systems and other information integration systems associated with real-time data.