In this paper, the author designs the HSE management information system for chemical enterprises. The author takes the HSE management as a systematic project and takes into account the actual needs of Chinese chemical enterprises and designs and implements a HSE system that is more in line with the actual business for chemical enterprises in China. The HSE management information system designed in this paper can fully meet the characteristics of chemical enterprises in China and has achieved good results. HSP management system is an advanced management system which can effectively improve the internal management efficiency and management capabilities of chemical enterprises in China.