This paper mainly studies the management mechanism of chemical engineering production using a game model. This paper puts forward different assumptions for the government and chemical manufacturing enterprises in our country and analyzes the relationship between chemical enterprise safety production management level and the cost of production. Then by case analysis, we study the changes of safety management of the chemical enterprises which are under government supervision and punishment situations. Under the supervision of government, media and public, the chemical enterprises tend to strengthen the internal management system and perfect their own safety production supervision mechanism.