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This paper sets to analyze the management of transportation Safety of dangerous goods transportation by the airline companies. It adopts the preliminary hazard analysis to understand the risk factors in dangerous goods transportation for the airline companies, and selects the transportation method of dangerous goods based on the relative weights of the risk factors. The result is reached that the airline companies need to establish a hierarchical analysis approach in dangerous goods transportation with clear-cut management responsibilities. It is the conclusion of this paper that quality inspection on dangerous goods is an important direction for the constructing the transportation safety management system.