Acetylcolonesterase Inhibitor Potential in Cinnamon Seed Oil (cinnamomum Zeylanicum Nees) Lauraceae in Roraima, Brazil

Abstract

One of the oldest plants known and considered a symbol of wisdom in antiquity especially in China is cinnamon (Cinnamomum zeylanicum Nees). The objective of this work was to study the fixed oil extracted from cinnamon (Cinnamomum zeylanicum Nees) seeds regarding its biological potential for inhibition of acetylcholinesterase. The inhibitory activity test of hexane extract studied on the enzyme acetylcholinesterase was conducted based on Ellman spectrophotometric method. The percentage of acetylcholinesterase enzyme inhibition was 65.5%, being considered a potent inhibitor according to the literature standarts. In conclusion, the results indicate that the oil can be used in the pharmaceutical industry as part or to develop drugs for treatment of certain neurodegenerative diseases, such as Alzheimer's disease.
Keywords: Fixed oil, Biological activity, Neurodegenerative diseases, Alzheimer, Natural products.